Bioavailability of paracetamol, phenylephrine hydrochloride and guaifenesin in a fixed-combination syrup versus an oral reference product
نویسندگان
چکیده
منابع مشابه
Clinical assessment of the warming sensation accompanying flavor 316282 in a cold and cough syrup containing paracetamol, phenylephrine hydrochloride, and guaifenesin
OBJECTIVE The primary objective was to assess the warming sensation caused by flavor 316282 in a cold and cough product in the target population. METHODS A single-cohort, single-treatment arm, open-label study. Subjects received one 30-mL dose of syrup containing flavor 316282, paracetamol, phenylephrine hydrochloride, and guaifenesin and recorded onset and disappearance of any warming sensat...
متن کاملAbioequivalence study on two closantel oral suspensions in sheep: an Iranian product (fascinil®) versus flukiver® as a reference product
BACKGROUND: Closantel is a broad-spectrum antiparasiticagent and is widely used for the control of Fasciola spp. andHaemonchus spp. infestations in sheep and cattle. OBJECTIVES:The present study was carried out to evaluate the bioequivalenceof a domestic closantel formulation, Fascinil® (DamloranPharmaceutical Co., Iran), in comparison with Flukiver®(Janssen pharmaceutical Co., Belgium) in shee...
متن کاملPharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration
BACKGROUND AND OBJECTIVES Previously published studies have suggested the lack of a pharmacokinetic interaction between ibuprofen and paracetamol when they are delivered as a fixed-dose oral combination. The aim of this study was to determine the pharmacokinetic profile and safety of a fixed-dose intravenous (IV) combination, containing 3 mg/mL ibuprofen and 10 mg/mL paracetamol, in comparison ...
متن کاملComparative evaluation of four spectrophotometric methods for the simultaneous determination of paracetamol and phenylephrine hydrochloride in fixed dose pharmaceutical formulations
Chavada et al / Physical Chemistry 17(1) (2015) 6-15 7 2004; Sirajuddin et al., 2007) electrochemical (Fan et al., 2011; Ghadimi et al., 2013; Özcan and Sahin, 2011; Khaskheli et al., 2013) and chromatographic techniques (McEvoy et al., 2007; Mostafa, 2010; Németh, 2008). The rationale for the present work was to develop and validate four accurate, precise, simple and economical spectrophotomet...
متن کاملabioequivalence study on two closantel oral suspensions in sheep: an iranian product (fascinil®) versus flukiver® as a reference product
background: closantel is a broad-spectrum antiparasiticagent and is widely used for the control of fasciola spp. andhaemonchus spp. infestations in sheep and cattle. objectives:the present study was carried out to evaluate the bioequivalenceof a domestic closantel formulation, fascinil® (damloranpharmaceutical co., iran), in comparison with flukiver®(janssen pharmaceutical co., belgium) in shee...
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ژورنال
عنوان ژورنال: Journal of International Medical Research
سال: 2014
ISSN: 0300-0605,1473-2300
DOI: 10.1177/0300060513503762